Windows Vista x64 originally allowed you to disable enforced driver signing in the bootloader, but this was removed in RC2, and not present in RTM

this meant you have to go into the boot menu ( f8 ) every time you wanted to run an unsigned driver.

a new way has been found to disable driver signing permanently

open up a command prompt (usually start > run > cmd - hit enter)

in the command prompt enter the following

CODE
bcdedit.exe -set loadoptions DDISABLE_INTEGRITY_CHECKS


thanks goes out to Nalin at XBCD forums for finding this